The transcriptome profile of human trisomy 21 blood cells
نویسندگان
چکیده
منابع مشابه
Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) provide a novel option in cellular therapy and tissue engineering. Recent studies indicated that it is possible to obtain MSCs from peripheral blood by attachment ability to plastic surface. To evaluate adherent cells derived from peripheral blood, their expression profile and surface markers were investigated. The results of RT-PCR indicated that these cells expre...
متن کاملTranscriptome analysis of human autosomal trisomy.
We present transcriptome analyses of primary cultures of human fetal cells from pregnancies affected with trisomy 21 (t21) and trisomy 13 (t13). Pooled mRNA samples from t21 and t13 cases were used for comparative hybridizations to cDNA arrays with pooled mRNA from normal cells. When the array cDNAs were grouped by chromosomal location the relevant trisomic chromosome could be clearly identifie...
متن کاملMassive-Scale RNA-Seq Analysis of Non Ribosomal Transcriptome in Human Trisomy 21
Hybridization- and tag-based technologies have been successfully used in Down syndrome to identify genes involved in various aspects of the pathogenesis. However, these technologies suffer from several limits and drawbacks and, to date, information about rare, even though relevant, RNA species such as long and small non-coding RNAs, is completely missing. Indeed, none of published works has sti...
متن کاملThe impact of trisomy 21 on early human hematopoiesis
Although children with Down syndrome (DS) are not cancer-prone in general, they have a 150-fold increased risk of acute myeloid leukemia of DS (ML-DS) and a 33-fold increased risk of B-cell acute lymphoblastic leukemia (B-ALL). In virtually all cases of ML-DS, but not in other leukemias, the leukemic cells acquire N-terminal mutations in the GATA1 gene, a key hematopoietic transcription factor ...
متن کاملTrisomy 21 tilts the balance.
Approximately 5% of children with Down syndrome (DS) are born with a unique transient clonal megakariyo-erythroblastic proliferation disorder often called transient myeloproliferative disorder (TMD). Spontaneous recovery usually occurs within up to several months. However, about one-fifth of these patients will develop full-blown acute leukemia with biphenotypic megakaryocyticerythroid features...
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ژورنال
عنوان ژورنال: Human Genomics
سال: 2021
ISSN: 1479-7364
DOI: 10.1186/s40246-021-00325-4